Several medical specialties currently employ platelet-rich plasma (PRP). PRP’s use in dermatology has recently attracted more attention. It is utilised for a variety of purposes, including alopecia, skin rejuvenation, and scar revision, wound healing, and tissue regeneration.

PRP is a organic produce that is a component of the autologous blood plasma fraction having a platelet concentration greater than the reference level. It is made from patient’s blood that was drawn before centrifugation. Doctors should be better equipped to comprehend this novel therapy and sift and analyse the data about PRP accessible in the literature with the support of clinicians who are familiar with the biology, mechanism of action, and classification of PRP. 

The website of Plasmolifting Technologies offers, the high quality PRP-tubes for the platelet-rich plasma (PRP) production. 

Platelet Biology

All blood cells are descended from a single pluripotent stem cell that gives rise to many cell types. Precursors that can divide and mature are present in each of these cell series.

The bone marrow produces thrombocytes, also known as platelets. The smallest density of all blood cells, platelets is nucleated, discoid cellular components with various diameters and a density of about 2 m in diameter.

Between 150,000 and 400,000 platelets per litre are physiologically present in the bloodstream.

Several secretory granules found in platelets are essential to platelet function. Lysosomes, o-granules, and dense granules are the three different forms of granules. The majority of the three types of granules, 50–80 granules, are present in each platelet.

In general, platelets are in charge of the aggregation process. The primary role is to support homeostasis by adhesion, activation, and aggregation. Platelets get activated during a vascular lesion, and their granules release substances that aid in coagulation.

Although it was always believed that platelets exclusively had hemostatic action, modern advances in science and technology have given us a fresh understanding of platelets and their roles. 

According to studies, platelets are a rich source of GFs and cytokines that can influence angiogenesis, stem cell migration, inflammation, and cell proliferation.

Mechanism of Action in Alopecia

Proliferation, migration, cell differentiation, and angiogenesis are the four basic functions that the GFs and bioactive compounds in PRP support in the region of administration. The regulation of hair morphogenesis and cycle hair development is mediated by a number of cytokines and growth factors (GFs).

The dermal papilla cells generate growth factors (GFs) that keep the hair follicle in the anagen phase of the hair cycle, including hepatocyte growth factor, IGF-1, FGF-7, as well as growth factor for vascular endothelial. Upregulating these GFs in the DP cells, which increase in length the anagen phase, would thus be a possible target.

Conclusion

In the field of dermatology, PRP is being employed as a new therapeutic option for a variety of diseases, including trichology, wound healing, and aesthetic medicine. 

In this way, a physician should be able to choose a system that best suits their unique requirements for a certain indication by being aware of the biology and mechanism of action of the medication. 

Additionally, defining the PRP type in use will result in a standardisation of PRP, making it simpler to organise and comprehend the data that is accessible. This evaluation should act as a starting point for future studies on the application of PRP, we hope.